No one is safe from Kathy Griffin's comic darts - from Oprah Winfrey to Clay Aiken and Julia Roberts, our modern celebrity culture is ripped to shreds by her achingly funny observations and rapid fire wit. In both her stand-up act and her stints hosting several red-carpet events, Griffin has earned a no-holds-barred reputation. Griffin's background includes several television series - she was a regular cast member of Suddenly Susan, and had guest spots on shows such as Mad About You, ER and Seinfeld.